OCCURRENCE

Collection of biological samples - Maternal and fetal, 2015-16 Zika epidemic (Colombia)

最新版本 由 Instituto Nacional de Salud 發佈於 2021年3月16日 Instituto Nacional de Salud
The observation of congenital malformations associated with vertical transmission (mother-fetus) of Zika Virus (ZIKV) such as microcephaly, made ZIKV a global threat to health, especially for child development. In this scenario, the Instituto Nacional de Salud (INS) - Colombia, established the collection of biological samples of pregnant women with ZIKV infection collected in the context of intensified surveillance during the 2015-16 Zika epidemic in Colombia. The samples were collected in three cities in Colombia that presented the highest number of cases: Cali, Barranquilla, and Cúcuta. From this surveillance, 461 pregnant women were included. The database and its samples rest in the COMMAFEZ collection of the INS.... 增加顯示內容

說明

The observation of congenital malformations associated with vertical transmission (mother-fetus) of Zika Virus (ZIKV) such as microcephaly, made ZIKV a global threat to health, especially for child development. In this scenario, the Instituto Nacional de Salud (INS) - Colombia, established the collection of biological samples of pregnant women with ZIKV infection collected in the context of intensified surveillance during the 2015-16 Zika epidemic in Colombia. The samples were collected in three cities in Colombia that presented the highest number of cases: Cali, Barranquilla, and Cúcuta. From this surveillance, 461 pregnant women were included. The database and its samples rest in the COMMAFEZ collection of the INS.

La observación de malformaciones congénitas asociadas a la transmisión vertical (madre-feto) del virus del Zika (ZIKV) como la microcefalia, convirtió al ZIKV en una amenaza mundial para la salud, en especial para el desarrollo infantil. En este escenario, el Instituto Nacional de Salud – Colombia, estableció la colección de muestras biológicas de mujeres embarazadas con infección por ZIKV recolectadas en el marco de la vigilancia intensificada durante la epidemia del Zika en Colombia en el periodo 2015-2016. Las muestras fueron colectadas en tres ciudades de Colombia que presentaron el mayor número de casos: Cali, Barranquilla y Cúcuta. A partir de ésta vigilancia se incluyeron 461 gestantes. La base de datos y sus muestras reposan en la colección COMMAFEZ del Instituto Nacional de Salud.

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如何引用

研究者應依照以下指示引用此資源。:

Mercado Reyes M M, Benavides Ruiz M M, Alvarez Díaz D A, Corchuelo Chavarro S Y (2021): Collection of biological samples - Maternal and fetal, 2015-16 Zika epidemic (Colombia). v1.2. Instituto Nacional de Salud. Dataset/Occurrence. https://doi.org/10.15472/v1nfb5

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GBIF 註冊

此資源已向GBIF註冊,並指定以下之GBIF UUID: 22449b1e-8894-4ca1-b14a-d71a569b277b。  Instituto Nacional de Salud 發佈此資源,並經由Colombian Biodiversity Information System同意向GBIF註冊成為資料發佈者。

關鍵字

Occurrence; Specimen; Zika virus; Pregnancy; Colombia; FFPE; Histological Slides; Fetal; Maternal; Homo sapiens

聯絡資訊

資源建立者:

Marcela María Mercado Reyes
Subdirectora de Investigación Científica y Tecnológica
Instituto Nacional de Salud
Avenida calle 26 No. 51-20 - Zona 6 CAN
111321 Bogotá
Bogotá
CO
122077001315
https://www.ins.gov.co/Paginas/Inicio.aspx
Monica Marcela Benavides Ruiz
Líder de Laboratorio
Instituto Nacional de Salud
Avenida calle 26 No. 51-20 - Zona 6 CAN
111321 Bogotá
Bogotá
CO
122077001315
https://www.ins.gov.co/Paginas/Inicio.aspx
Diego Alejandro Alvarez Díaz
Profesional Especializado
Instituto Nacional de Salud
Avenida calle 26 No. 51-20 - Zona 6 CAN
111321 Bogotá
Bogotá
CO
+57122077001315
https://www.ins.gov.co/Paginas/Inicio.aspx
Sheryll Yohana Corchuelo Chavarro
Profesional Especializado
Instituto Nacional de Salud
Avenida calle 26 No. 51-20 - Zona 6 CAN
111321 Bogotá
Bogotá
CO
122077001315
https://www.ins.gov.co/Paginas/Inicio.aspx

可回覆此資源相關問題者:

Marcela María Mercado Reyes
Subdirectora de Investigación Científica y Tecnológica
Instituto Nacional de Salud
Avenida calle 26 No. 51-20 - Zona 6 CAN
111321 Bogotá
Bogotá
CO
122077001315
https://www.ins.gov.co/Paginas/Inicio.aspx

元數據填寫者:

Diego Alejandro Alvarez Díaz
Profesional Especializado
Instituto Nacional de Salud
Avenida calle 26 No. 51-20 - Zona 6 CAN
111321 Bogotá
Bogotá
CO
(1)2207700 ext 1315
https://www.ins.gov.co/Paginas/Inicio.aspx

與此資源的相關者:

研究主持人
Marcela María Mercado Reyes
Subdirectora de Investigación Científica y Tecnológica
Instituto Nacional de Salud
Avenida calle 26 No. 51-20 - Zona 6 CAN
111321 Bogotá
Bogotá
CO
5+72207700
https://www.ins.gov.co/Paginas/Inicio.aspx
擁有者
Instituto Nacional de Salud
Titular
Instituto Nacional de Salud
Avenida calle 26 No. 51-20 - Zona 6 CAN
111321 Bogotá
Bogotá
CO
+5712207700
https://www.ins.gov.co/Paginas/Inicio.aspx
作者
Diego Alejandro Álvarez Díaz
Profesional Especializado
Instituto Nacional de Salud
Avenida calle 26 No. 51-20 - Zona 6 CAN
111321 Bogotá
Bogotá
CO
+57122077001315
https://www.ins.gov.co/Paginas/Inicio.aspx
作者
Sheryll Yohana Corchuelo Chavarro
Profesional Especializado
Instituto Nacional de Salud
Avenida calle 26 No. 51-20 - Zona 6 CAN
111321 Bogotá
Bogotá
CO
+57122077001262
https://www.ins.gov.co/Paginas/Inicio.aspx
作者
Monica Marcela Benavides Ruiz
Líder de Laboratorio
Instituto Nacional de Salud
Avenida calle 26 No. 51-20 - Zona 6 CAN
111321 Bogotá
Bogotá
CO
+5712207700
https://www.ins.gov.co/Paginas/Inicio.aspx

地理涵蓋範圍

The samples were collected in the cities of Cali, Barranquilla, and Cúcuta.

界定座標範圍 緯度南界 經度西界 [3.272, -77.014], 緯度北界 經度東界 [11.157, -71.411]

分類群涵蓋範圍

Zika Virus was classified at the species level

Species  Zika Virus (ZIKV)

時間涵蓋範圍

起始日期 / 結束日期 2015-09-01 / 2016-12-30

計畫資料

During September 2015 to December 2016, more than 100,000 cases of ZIKV infection were notified to SIVIGILA, of which, more than 18,000 were pregnant women. Due to the greater impact of this agent when the infection occurs during pregnancy, the INS and the CDC implemented the project "Intensified Surveillance of Pregnant Women with Zika (VEZ)" in three cities of Colombia that presented the highest number of cases: Cali, Barranquilla, and Cúcuta. Within the framework of this project, more than 1200 pregnant women and her babies were included for follow-up during pregnancy, childbirth and until the first 2 years of their life.

計畫名稱 Vigilancia Intensificada de Embarazadas con Zika
辨識碼 VEZ
經費來源 Instituto Nacional de Salud - Dirección de Redes en Salud Pública y Dirección de Investigación en Salud Pública, Sistema de Vigilancia en Salud Pública. CDC - Centers for Diseases Control and Prevention.
研究區域描述 Lending Institutions of Health Services (EPS) from Cali, Barranquilla, and Cúcuta.
研究設計描述 Main goal To assess the relationship between Zika virus infection during pregnancy and adverse outcomes in pregnancy, childbirth and in the infant until the first two years of life. The methodology was divided into three phases that consisted of: 1) Case analysis: surveillance of microcephaly and congenital defects (CD) of the central nervous system (CNS), 2) Surveillance of pregnant women with Zika and 3) Follow-up of infants with prenatal exposure to Zika virus.

參與計畫的人員:

研究主持人
Marcela María Mercado Reyes

取樣方法

Biological material was collected from pregnant women with suspected ZIKV infection who attended for medical consultation at Health Services Provider Institutions in the cities of Cali, Barranquilla, and Cúcuta. 2833 samples were cryopreserved in saline solution at -80°C, including umbilical cord 36%, placenta 35%, cord blood 11%, serum 10%, urine 5%, ovular membranes 1%, amniotic fluid 1% and other tissues 1%. 1762 samples of placental, cord and fetal tissues were Formalin-Fixed and Paraffin-Embedded (FFPE) and 3063 slides with tissue sections were processed for histopathological analysis.

研究範圍 Valle del Cauca (Cali) Atlántico (Barranquilla) Norte de Santander (Cúcuta)
品質控管 The samples were taken by trained biomedical personnel throughout the process, complying with the biosafety standards for the handling of the samples and following the INS Sample Collection instructions (INT-R03.318-006), which was authorized in the framework of the epidemiological surveillance of the Zika virus developed by the INS and the sample management protocol in the epidemiological surveillance mission studies carried out by the Technical Directorate of Surveillance and Risk Analysis. Also, the guidelines of the Manual for obtaining and sending samples for analysis of events of interest in public health carried out by the INS in 2011, were followed. Controlled vocabulary adjustment in: - Record element: type; - Geographical element: county.

方法步驟描述:

  1. 1) Identification of symptomatic pregnant women: Pregnant women with suspected infection by ZIKV were notified to the public health surveillance system of INS SIVIGILA. Once identified, they were invited to participate in the follow-up of their pregnancy and their children until they were two years old. 2) Once the informed consent was signed, samples were taken of the placenta, umbilical cord, urine, amniotic fluid, and umbilical cord blood during delivery, in order to subsequently demonstrate the presence of Zika virus in any of these. 3) Placental Processing Surveillance program for pregnant women with Zika - sent in neutral buffered formalin. 4) Shipment of placental paraffin blocks in the framework of ZIKA research (VEZ program). 5) Histopathological analysis. 6) Data management: The information associated with the tissues rests physically in the file of the Maternal and Perinatal Health (INS) group and a magnetic medium database. Data collected from the clinical history and epidemiological notification form of SIVIGILA.

收藏資料

蒐藏名稱 Colección de muestras biológicas – Maternas y fetales, epidemia del Zika 2015-2016
標本保存方法 Formalin,  Deep frozen,  Microscopic preparation,  Other

引用文獻

  1. 1. Revista-Semana. La generación del zika: así viven los niños que nacieron en medio de la epidemia. Semana [Newsletter] 2019 April 04, 2019; Available from: https://www.semana.com/vida-moderna/articulo/la-generacion-del-zika-asi-viven-los-ninos-que-nacieron-en-medio-de-la-epidemia/610454. 2. Cuevas, E.L., et al., Preliminary Report of Microcephaly Potentially Associated with Zika Virus Infection During Pregnancy - Colombia, January-November 2016. MMWR Morb Mortal Wkly Rep, 2016. 65(49): p. 1409-1413. 3. Fernandez, M.P., et al., Ocular Histopathologic Features of Congenital Zika Syndrome. JAMA Ophthalmol, 2017. 135(11): p. 1163-1169. 4. Mercado-Reyes, M., et al., Dengue, chikungunya and zika virus coinfection: results of the national surveillance during the zika epidemic in Colombia. Epidemiol Infect, 2019. 147: p. e77. 5. Parra-Saavedra, M., et al., Serial Head and Brain Imaging of 17 Fetuses With Confirmed Zika Virus Infection in Colombia, South America. Obstet Gynecol, 2017. 130(1): p. 207-212. 6. Instituto Nacional de Salud. Circular externa 0020 de 2016. Nuevos lineamientos para el fortalecimiento de la vigilancia por laboratorio del virus Zika en el territorio Colombiano.www.ins..gov.co/Normativ1dad/Circulares/CIRCULAR%200063%20DE%202015.pdf.

額外的詮釋資料

目的 To ensure the storage and availability of biological material obtained during the Zika epidemic in Colombia (2015-2016), for research associated with the understanding of this disease
替代的識別碼 10.15472/v1nfb5
22449b1e-8894-4ca1-b14a-d71a569b277b
https://ipt.biodiversidad.co/sib/resource?r=conmmafez