Description
The observation of congenital malformations associated with vertical transmission (mother-fetus) of Zika Virus (ZIKV) such as microcephaly, made ZIKV a global threat to health, especially for child development. In this scenario, the Instituto Nacional de Salud (INS) - Colombia, established the collection of biological samples of pregnant women with ZIKV infection collected in the context of intensified surveillance during the 2015-16 Zika epidemic in Colombia. The samples were collected in three cities in Colombia that presented the highest number of cases: Cali, Barranquilla, and Cúcuta. From this surveillance, 461 pregnant women were included. The database and its samples rest in the COMMAFEZ collection of the INS.
La observación de malformaciones congénitas asociadas a la transmisión vertical (madre-feto) del virus del Zika (ZIKV) como la microcefalia, convirtió al ZIKV en una amenaza mundial para la salud, en especial para el desarrollo infantil. En este escenario, el Instituto Nacional de Salud – Colombia, estableció la colección de muestras biológicas de mujeres embarazadas con infección por ZIKV recolectadas en el marco de la vigilancia intensificada durante la epidemia del Zika en Colombia en el periodo 2015-2016. Las muestras fueron colectadas en tres ciudades de Colombia que presentaron el mayor número de casos: Cali, Barranquilla y Cúcuta. A partir de ésta vigilancia se incluyeron 461 gestantes. La base de datos y sus muestras reposan en la colección COMMAFEZ del Instituto Nacional de Salud.
Enregistrements de données
Les données de cette ressource occurrence ont été publiées sous forme d'une Archive Darwin Core (Darwin Core Archive ou DwC-A), le format standard pour partager des données de biodiversité en tant qu'ensemble d'un ou plusieurs tableurs de données. Le tableur de données du cœur de standard (core) contient 461 enregistrements.
Cet IPT archive les données et sert donc de dépôt de données. Les données et métadonnées de la ressource sont disponibles pour téléchargement dans la section téléchargements. Le tableau des versions liste les autres versions de chaque ressource rendues disponibles de façon publique et permet de tracer les modifications apportées à la ressource au fil du temps.
Téléchargements
Téléchargez la dernière version de la ressource en tant qu'Archive Darwin Core (DwC-A), ou les métadonnées de la ressource au format EML ou RTF :
| Données sous forme de fichier DwC-A (zip) | télécharger 461 enregistrements dans Anglais (15 kB) - Fréquence de mise à jour: quand cela est nécessaire |
|---|---|
| Métadonnées sous forme de fichier EML | télécharger dans Anglais (22 kB) |
| Métadonnées sous forme de fichier RTF | télécharger dans Anglais (15 kB) |
Versions
Le tableau ci-dessous n'affiche que les versions publiées de la ressource accessibles publiquement.
Comment citer
Les chercheurs doivent citer cette ressource comme suit:
Mercado Reyes M M, Benavides Ruiz M M, Alvarez Díaz D A, Corchuelo Chavarro S Y (2021): Collection of biological samples - Maternal and fetal, 2015-16 Zika epidemic (Colombia). v1.2. Instituto Nacional de Salud. Dataset/Occurrence. https://doi.org/10.15472/v1nfb5
Droits
Les chercheurs doivent respecter la déclaration de droits suivante:
L’éditeur et détenteur des droits de cette ressource est Instituto Nacional de Salud. This work is licensed under a Creative Commons Attribution Non Commercial (CC-BY-NC) 4.0 License.
Enregistrement GBIF
Cette ressource a été enregistrée sur le portail GBIF, et possède l'UUID GBIF suivante : 22449b1e-8894-4ca1-b14a-d71a569b277b. Instituto Nacional de Salud publie cette ressource, et est enregistré dans le GBIF comme éditeur de données avec l'approbation du Colombian Biodiversity Information System.
Mots-clé
Occurrence; Specimen; Zika virus; Pregnancy; Colombia; FFPE; Histological Slides; Fetal; Maternal; Homo sapiens
Contacts
Personne ayant créé cette ressource:
Personne pouvant répondre aux questions sur la ressource:
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Couverture géographique
The samples were collected in the cities of Cali, Barranquilla, and Cúcuta.
| Enveloppe géographique | Sud Ouest [3,272, -77,014], Nord Est [11,157, -71,411] |
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Couverture taxonomique
Zika Virus was classified at the species level
| Species | Zika Virus (ZIKV) |
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Couverture temporelle
| Date de début / Date de fin | 2015-09-01 / 2016-12-30 |
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Données sur le projet
During September 2015 to December 2016, more than 100,000 cases of ZIKV infection were notified to SIVIGILA, of which, more than 18,000 were pregnant women. Due to the greater impact of this agent when the infection occurs during pregnancy, the INS and the CDC implemented the project "Intensified Surveillance of Pregnant Women with Zika (VEZ)" in three cities of Colombia that presented the highest number of cases: Cali, Barranquilla, and Cúcuta. Within the framework of this project, more than 1200 pregnant women and her babies were included for follow-up during pregnancy, childbirth and until the first 2 years of their life.
| Titre | Vigilancia Intensificada de Embarazadas con Zika |
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| Identifiant | VEZ |
| Financement | Instituto Nacional de Salud - Dirección de Redes en Salud Pública y Dirección de Investigación en Salud Pública, Sistema de Vigilancia en Salud Pública. CDC - Centers for Diseases Control and Prevention. |
| Description du domaine d'étude / de recherche | Lending Institutions of Health Services (EPS) from Cali, Barranquilla, and Cúcuta. |
| Description du design | Main goal To assess the relationship between Zika virus infection during pregnancy and adverse outcomes in pregnancy, childbirth and in the infant until the first two years of life. The methodology was divided into three phases that consisted of: 1) Case analysis: surveillance of microcephaly and congenital defects (CD) of the central nervous system (CNS), 2) Surveillance of pregnant women with Zika and 3) Follow-up of infants with prenatal exposure to Zika virus. |
Les personnes impliquées dans le projet:
Méthodes d'échantillonnage
Biological material was collected from pregnant women with suspected ZIKV infection who attended for medical consultation at Health Services Provider Institutions in the cities of Cali, Barranquilla, and Cúcuta. 2833 samples were cryopreserved in saline solution at -80°C, including umbilical cord 36%, placenta 35%, cord blood 11%, serum 10%, urine 5%, ovular membranes 1%, amniotic fluid 1% and other tissues 1%. 1762 samples of placental, cord and fetal tissues were Formalin-Fixed and Paraffin-Embedded (FFPE) and 3063 slides with tissue sections were processed for histopathological analysis.
| Etendue de l'étude | Valle del Cauca (Cali) Atlántico (Barranquilla) Norte de Santander (Cúcuta) |
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| Contrôle qualité | The samples were taken by trained biomedical personnel throughout the process, complying with the biosafety standards for the handling of the samples and following the INS Sample Collection instructions (INT-R03.318-006), which was authorized in the framework of the epidemiological surveillance of the Zika virus developed by the INS and the sample management protocol in the epidemiological surveillance mission studies carried out by the Technical Directorate of Surveillance and Risk Analysis. Also, the guidelines of the Manual for obtaining and sending samples for analysis of events of interest in public health carried out by the INS in 2011, were followed. Controlled vocabulary adjustment in: - Record element: type; - Geographical element: county. |
Description des étapes de la méthode:
- 1) Identification of symptomatic pregnant women: Pregnant women with suspected infection by ZIKV were notified to the public health surveillance system of INS SIVIGILA. Once identified, they were invited to participate in the follow-up of their pregnancy and their children until they were two years old. 2) Once the informed consent was signed, samples were taken of the placenta, umbilical cord, urine, amniotic fluid, and umbilical cord blood during delivery, in order to subsequently demonstrate the presence of Zika virus in any of these. 3) Placental Processing Surveillance program for pregnant women with Zika - sent in neutral buffered formalin. 4) Shipment of placental paraffin blocks in the framework of ZIKA research (VEZ program). 5) Histopathological analysis. 6) Data management: The information associated with the tissues rests physically in the file of the Maternal and Perinatal Health (INS) group and a magnetic medium database. Data collected from the clinical history and epidemiological notification form of SIVIGILA.
Données de collection
| Nom de la collection | Colección de muestras biológicas – Maternas y fetales, epidemia del Zika 2015-2016 |
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| Méthode de conservation des spécimens | Formalin, Deep frozen, Microscopic preparation, Other |
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Citations bibliographiques
- 1. Revista-Semana. La generación del zika: así viven los niños que nacieron en medio de la epidemia. Semana [Newsletter] 2019 April 04, 2019; Available from: https://www.semana.com/vida-moderna/articulo/la-generacion-del-zika-asi-viven-los-ninos-que-nacieron-en-medio-de-la-epidemia/610454. 2. Cuevas, E.L., et al., Preliminary Report of Microcephaly Potentially Associated with Zika Virus Infection During Pregnancy - Colombia, January-November 2016. MMWR Morb Mortal Wkly Rep, 2016. 65(49): p. 1409-1413. 3. Fernandez, M.P., et al., Ocular Histopathologic Features of Congenital Zika Syndrome. JAMA Ophthalmol, 2017. 135(11): p. 1163-1169. 4. Mercado-Reyes, M., et al., Dengue, chikungunya and zika virus coinfection: results of the national surveillance during the zika epidemic in Colombia. Epidemiol Infect, 2019. 147: p. e77. 5. Parra-Saavedra, M., et al., Serial Head and Brain Imaging of 17 Fetuses With Confirmed Zika Virus Infection in Colombia, South America. Obstet Gynecol, 2017. 130(1): p. 207-212. 6. Instituto Nacional de Salud. Circular externa 0020 de 2016. Nuevos lineamientos para el fortalecimiento de la vigilancia por laboratorio del virus Zika en el territorio Colombiano.www.ins..gov.co/Normativ1dad/Circulares/CIRCULAR%200063%20DE%202015.pdf.
Métadonnées additionnelles
| Objet | To ensure the storage and availability of biological material obtained during the Zika epidemic in Colombia (2015-2016), for research associated with the understanding of this disease |
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| Identifiants alternatifs | 10.15472/v1nfb5 |
| 22449b1e-8894-4ca1-b14a-d71a569b277b | |
| https://ipt.biodiversidad.co/sib/resource?r=conmmafez |