Descripción
The observation of congenital malformations associated with vertical transmission (mother-fetus) of Zika Virus (ZIKV) such as microcephaly, made ZIKV a global threat to health, especially for child development. In this scenario, the Instituto Nacional de Salud (INS) - Colombia, established the collection of biological samples of pregnant women with ZIKV infection collected in the context of intensified surveillance during the 2015-16 Zika epidemic in Colombia. The samples were collected in three cities in Colombia that presented the highest number of cases: Cali, Barranquilla, and Cúcuta. From this surveillance, 461 pregnant women were included. The database and its samples rest in the COMMAFEZ collection of the INS.
La observación de malformaciones congénitas asociadas a la transmisión vertical (madre-feto) del virus del Zika (ZIKV) como la microcefalia, convirtió al ZIKV en una amenaza mundial para la salud, en especial para el desarrollo infantil. En este escenario, el Instituto Nacional de Salud – Colombia, estableció la colección de muestras biológicas de mujeres embarazadas con infección por ZIKV recolectadas en el marco de la vigilancia intensificada durante la epidemia del Zika en Colombia en el periodo 2015-2016. Las muestras fueron colectadas en tres ciudades de Colombia que presentaron el mayor número de casos: Cali, Barranquilla y Cúcuta. A partir de ésta vigilancia se incluyeron 461 gestantes. La base de datos y sus muestras reposan en la colección COMMAFEZ del Instituto Nacional de Salud.
Registros
Los datos en este recurso de registros biológicos han sido publicados como Archivo Darwin Core(DwC-A), el cual es un formato estándar para compartir datos de biodiversidad como un conjunto de una o más tablas de datos. La tabla de datos del core contiene 461 registros.
Este IPT archiva los datos y, por lo tanto, sirve como repositorio de datos. Los datos y los metadatos del recurso están disponibles para su descarga en la sección descargas. La tabla versiones enumera otras versiones del recurso que se han puesto a disposición del público y permite seguir los cambios realizados en el recurso a lo largo del tiempo.
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Versiones
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¿Cómo referenciar?
Los usuarios deben citar este trabajo de la siguiente manera:
Mercado Reyes M M, Benavides Ruiz M M, Alvarez Díaz D A, Corchuelo Chavarro S Y (2021): Collection of biological samples - Maternal and fetal, 2015-16 Zika epidemic (Colombia). v1.2. Instituto Nacional de Salud. Dataset/Occurrence. https://doi.org/10.15472/v1nfb5
Derechos
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El publicador y propietario de los derechos de este trabajo es Instituto Nacional de Salud. This work is licensed under a Creative Commons Attribution Non Commercial (CC-BY-NC) 4.0 License.
Registro GBIF
Este recurso ha sido registrado en GBIF con el siguiente UUID: 22449b1e-8894-4ca1-b14a-d71a569b277b. Instituto Nacional de Salud publica este recurso, y está registrado en GBIF como un publicador de datos avalado por Colombian Biodiversity Information System.
Palabras clave
Occurrence; Specimen; Zika virus; Pregnancy; Colombia; FFPE; Histological Slides; Fetal; Maternal; Homo sapiens
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Cobertura geográfica
The samples were collected in the cities of Cali, Barranquilla, and Cúcuta.
| Coordenadas límite | Latitud Mínima Longitud Mínima [3,272, -77,014], Latitud Máxima Longitud Máxima [11,157, -71,411] |
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Cobertura taxonómica
Zika Virus was classified at the species level
| Especie | Zika Virus (ZIKV) |
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Cobertura temporal
| Fecha Inicial / Fecha Final | 2015-09-01 / 2016-12-30 |
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Datos del proyecto
During September 2015 to December 2016, more than 100,000 cases of ZIKV infection were notified to SIVIGILA, of which, more than 18,000 were pregnant women. Due to the greater impact of this agent when the infection occurs during pregnancy, the INS and the CDC implemented the project "Intensified Surveillance of Pregnant Women with Zika (VEZ)" in three cities of Colombia that presented the highest number of cases: Cali, Barranquilla, and Cúcuta. Within the framework of this project, more than 1200 pregnant women and her babies were included for follow-up during pregnancy, childbirth and until the first 2 years of their life.
| Título | Vigilancia Intensificada de Embarazadas con Zika |
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| Identificador | VEZ |
| Fuentes de Financiación | Instituto Nacional de Salud - Dirección de Redes en Salud Pública y Dirección de Investigación en Salud Pública, Sistema de Vigilancia en Salud Pública. CDC - Centers for Diseases Control and Prevention. |
| Descripción del área de estudio | Lending Institutions of Health Services (EPS) from Cali, Barranquilla, and Cúcuta. |
| Descripción del diseño | Main goal To assess the relationship between Zika virus infection during pregnancy and adverse outcomes in pregnancy, childbirth and in the infant until the first two years of life. The methodology was divided into three phases that consisted of: 1) Case analysis: surveillance of microcephaly and congenital defects (CD) of the central nervous system (CNS), 2) Surveillance of pregnant women with Zika and 3) Follow-up of infants with prenatal exposure to Zika virus. |
Personas asociadas al proyecto:
Métodos de muestreo
Biological material was collected from pregnant women with suspected ZIKV infection who attended for medical consultation at Health Services Provider Institutions in the cities of Cali, Barranquilla, and Cúcuta. 2833 samples were cryopreserved in saline solution at -80°C, including umbilical cord 36%, placenta 35%, cord blood 11%, serum 10%, urine 5%, ovular membranes 1%, amniotic fluid 1% and other tissues 1%. 1762 samples of placental, cord and fetal tissues were Formalin-Fixed and Paraffin-Embedded (FFPE) and 3063 slides with tissue sections were processed for histopathological analysis.
| Área de Estudio | Valle del Cauca (Cali) Atlántico (Barranquilla) Norte de Santander (Cúcuta) |
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| Control de Calidad | The samples were taken by trained biomedical personnel throughout the process, complying with the biosafety standards for the handling of the samples and following the INS Sample Collection instructions (INT-R03.318-006), which was authorized in the framework of the epidemiological surveillance of the Zika virus developed by the INS and the sample management protocol in the epidemiological surveillance mission studies carried out by the Technical Directorate of Surveillance and Risk Analysis. Also, the guidelines of the Manual for obtaining and sending samples for analysis of events of interest in public health carried out by the INS in 2011, were followed. Controlled vocabulary adjustment in: - Record element: type; - Geographical element: county. |
Descripción de la metodología paso a paso:
- 1) Identification of symptomatic pregnant women: Pregnant women with suspected infection by ZIKV were notified to the public health surveillance system of INS SIVIGILA. Once identified, they were invited to participate in the follow-up of their pregnancy and their children until they were two years old. 2) Once the informed consent was signed, samples were taken of the placenta, umbilical cord, urine, amniotic fluid, and umbilical cord blood during delivery, in order to subsequently demonstrate the presence of Zika virus in any of these. 3) Placental Processing Surveillance program for pregnant women with Zika - sent in neutral buffered formalin. 4) Shipment of placental paraffin blocks in the framework of ZIKA research (VEZ program). 5) Histopathological analysis. 6) Data management: The information associated with the tissues rests physically in the file of the Maternal and Perinatal Health (INS) group and a magnetic medium database. Data collected from the clinical history and epidemiological notification form of SIVIGILA.
Datos de la colección
| Nombre de la Colección | Colección de muestras biológicas – Maternas y fetales, epidemia del Zika 2015-2016 |
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| Métodos de preservación de los ejemplares | Formalina, Congelado, Preparación microscópica, Otro |
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Referencias bibliográficas
- 1. Revista-Semana. La generación del zika: así viven los niños que nacieron en medio de la epidemia. Semana [Newsletter] 2019 April 04, 2019; Available from: https://www.semana.com/vida-moderna/articulo/la-generacion-del-zika-asi-viven-los-ninos-que-nacieron-en-medio-de-la-epidemia/610454. 2. Cuevas, E.L., et al., Preliminary Report of Microcephaly Potentially Associated with Zika Virus Infection During Pregnancy - Colombia, January-November 2016. MMWR Morb Mortal Wkly Rep, 2016. 65(49): p. 1409-1413. 3. Fernandez, M.P., et al., Ocular Histopathologic Features of Congenital Zika Syndrome. JAMA Ophthalmol, 2017. 135(11): p. 1163-1169. 4. Mercado-Reyes, M., et al., Dengue, chikungunya and zika virus coinfection: results of the national surveillance during the zika epidemic in Colombia. Epidemiol Infect, 2019. 147: p. e77. 5. Parra-Saavedra, M., et al., Serial Head and Brain Imaging of 17 Fetuses With Confirmed Zika Virus Infection in Colombia, South America. Obstet Gynecol, 2017. 130(1): p. 207-212. 6. Instituto Nacional de Salud. Circular externa 0020 de 2016. Nuevos lineamientos para el fortalecimiento de la vigilancia por laboratorio del virus Zika en el territorio Colombiano.www.ins..gov.co/Normativ1dad/Circulares/CIRCULAR%200063%20DE%202015.pdf.
Metadatos adicionales
| Propósito | To ensure the storage and availability of biological material obtained during the Zika epidemic in Colombia (2015-2016), for research associated with the understanding of this disease |
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| Identificadores alternativos | 10.15472/v1nfb5 |
| 22449b1e-8894-4ca1-b14a-d71a569b277b | |
| https://ipt.biodiversidad.co/sib/resource?r=conmmafez |